science & techNLM Circulating Now1928–1951 · Copenhagen, Denmark

How We Help the Body Breathe

the gist

Artificial breathing is far older than modern medicine, but its machines split into two families. Positive-pressure devices push air into the lungs, while negative-pressure devices lower the pressure around the chest so the lungs inflate, as they do naturally. The iron lung, developed by Philip Drinker and Louis Agassiz Shaw at Harvard in 1928–1929, was the best-known negative-pressure machine and kept polio patients alive. A 1951 polio outbreak in Copenhagen exposed its limits, and Bjorn Ibsen's team showed that forcing air in through a tracheostomy saved more lives, marking the shift toward positive pressure that underlies modern intensive care.

how it works

Lungs expand when the pressure around them falls below the air pressure outside the body. Negative-pressure machines copy this by sealing the body in a chamber and lowering the pressure around the chest. Positive-pressure machines do the reverse, pushing air into the airways, which is simpler and more controllable but can damage lungs if pressure is too high.

so what

Every modern ventilator and ICU traces back to this switch. The history shows why breathing support is so hard to get right: too much pressure can injure lungs as badly as no treatment at all.

the bigger pattern

Medicine often swings between competing approaches; here, the preference for negative pressure lasted until a crisis forced a change. Similar shifts happened when the polio epidemics showed that large, costly machines could not meet demand.

fun fact

The iron lung was a sealed metal tank in which the patient's head stuck out through a collar, while the rest of the body sat inside.

U.S. National Library of Medicine

Illustrative photo · Photo Credit: Content Providers(s): CDC/GHO/Mary Hilpertsha…, Public domain, via Wikimedia Commons