science & techWellcome Collection

Unravelling genetic origins from the potato to cinchona

the gist

Palaeogenomics uses DNA from museum specimens and ancient remains to trace where living crops and species came from. Potatoes were domesticated in southern Peru and the Andes roughly 7,000 to 10,000 years ago, and the Andes still hold more than 4,000 native varieties. Researchers found that modern European potatoes trace back to a mix of Chilean and Andean historical specimens, later crossed with wild relatives, and one of those specimens was collected by Charles Darwin on Chiloé Island. The same method has rewritten history. Herbarium samples from the 19th century showed that the strain behind the Irish Famine of 1840 was not the US-1 strain that dominated until the 1970s, but a different South American lineage. Such work helps trace food security risks and guides conservation of threatened species, such as cinchona, the fever tree.

how it works

Researchers extract DNA from dried herbarium specimens and ancient remains, which is fragile and only available in small amounts. They use specialised lab protocols and computational analysis to read the genomes, then compare them with modern varieties. Matching patterns reveal which populations a crop descends from and how a pathogen spread over time.

so what

Genomic analysis of old collections can reveal the history of crops and disease, which matters for protecting food security and biodiversity. Museum samples turn out to be a living archive.

fun fact

Charles Darwin collected a potato plant on Chiloé Island during the voyage of the Beagle, and that specimen became part of the genetic story of European potatoes.

Wellcome Collection · CC BY 4.0

Illustrative photo · Scott Bauer, USDA ARS, Public domain, via Wikimedia Commons