17:32supplementary video · Institute of Human Anatomy on YouTube ↗
mind & bodyanalysisThe Conversation (UK)
The collagen craze promises younger-looking skin, but the evidence is less convincing
Collagen is the body's most abundant protein, the structural scaffolding of skin, tendons and other tissue, and at least 28 types exist. Supplements promise to replace what ageing erodes, but swallowed collagen is broken down in digestion into smaller pieces, so it is not delivered intact to your face or knees. Some trials report better skin hydration or elasticity, yet a 2025 review of 23 trials found the apparent benefit vanished when only higher-quality or non-industry-funded studies were counted. Collagen creams fare no better: the molecules are too large to pass through intact skin, so they mostly work as moisturisers.
Digestion splits collagen into amino acids and short peptides, which the body can use to build any protein it needs. Nothing directs them to the skin. Some researchers suggest peptides might signal skin cells to make more collagen, but this remains contested.
The collagen boom shows how a plausible-sounding story, that eating a protein replaces that protein, can sell far ahead of evidence. Claims are worth checking against independent trials, especially when the studies are funded by the sellers.
Salmon or trout DNA, in the form of an ingredient called PDRN, is now marketed in skincare, based largely on its use in wound healing rather than on evidence for rejuvenating healthy skin.
The Conversation
