mind & bodyanalysisOur World in Data1990s–present · United States

The United States has by far the highest death rate from opioids of any country

the gist

The United States has a far higher death rate from illicit drugs than any other country, and opioids account for much of the gap. Deaths from synthetic opioids such as fentanyl rose steeply in the 2010s and early 2020s, driven by illegal supply that is far more potent per dose than heroin. Prescription opioids started the wave in the 1990s and 2000s by fuelling dependence, and many users later switched to cheaper street drugs. Fentanyl is strong enough that tiny amounts can be lethal, which is why overdose numbers climbed so fast.

how it works

Opioids bind to receptors that control pain and breathing, and high doses slow breathing until it stops. Fentanyl is many times stronger than morphine, so small variations in dose or purity can cause fatal overdoses.

so what

Overdose deaths have become a leading cause of death for young adults in the US, making drug policy and treatment a central public health issue.

the bigger pattern

The US opioid crisis is often described in three waves: prescription opioids, then heroin, then synthetic opioids. Each shift followed changes in supply, as crackdowns on prescriptions pushed users toward cheaper and more dangerous alternatives.

fun fact

Morphine was first isolated from opium in 1804 by the German pharmacist Friedrich Sertürner.

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