How to predict the behavior of molecules from scant data
the gist
Researchers at MIT built CheMeleon, a machine-learning model that is first pre-trained on about a million molecules to learn basic chemistry. It then adapts to predict specific properties such as potency, toxicity and solubility with only limited data. The approach aims to make early drug and chemical design faster when experimental data is scarce. The model is a single base system that is fine-tuned for each new task. The work targets specialists in computational chemistry.
so what
It may reduce the lab testing needed to screen new molecules. Its direct impact is mainly within drug discovery research.
history·Wikipedia·classic1336–1565 · Karnataka, India
Hampi was once one of the world's largest cities, until its Vijayanagara capital was destroyed in 1565
the gist
Hampi is a UNESCO World Heritage Site in Karnataka, India, with more than 1,600 surviving remains spread over 4,100 hectares. It was the capital of the Vijayanagara Empire from 1336 to 1565. Travellers from Persia and Portugal described it as a prosperous, wealthy and grand city with temples, markets and farms along the Tungabhadra River. By 1500 it was estimated to be the world's second-largest city after Beijing, and probably India's richest at the time. In 1565 a coalition of Muslim sultanates defeated the Vijayanagara Empire, its capital was conquered and destroyed, and the city was left in ruins. Hampi remains a religious centre, with the active Virupaksha Temple at its heart.
how it works
The city was built around a fortified core with temples, markets and water structures along the river, supplied by an extensive network of roads and waterworks. When the empire fell, the city was not rebuilt, so its stone monuments were left standing.
so what
Hampi shows how quickly a great city can vanish after a military defeat, and how a ruined capital can remain sacred. Its ruins give historians a view of medieval South Asia that few other sites can match.
fun fact
The name Hampi comes from Pampa, an old name for the Tungabhadra River.
From Wikipedia, the free encyclopedia · text CC BY-SA 4.0
False allegations about Singapore’s hand in Indonesia’s markets and a made-up meeting
from CNA
CNA Verify has found close to 400 posts pushing falsehoods tying Singapore to Indonesia’s stock market rout and to a secret meeting that never took place. Together, they drew nearly 12 million views, and some were circulated by accounts that appeared to be working in concert, across multiple social media platforms.
Here’s how the disinformation campaign targeting Singapore was uncovered.
