mind & bodyanalysisThe Conversation (Australia)

Could these bacteria-killing viruses help fight antibiotic resistance? A new discovery takes us closer

the gist

Bacteriophages, or phages, are viruses that infect and kill bacteria, and they are among the most abundant biological entities on Earth. Doctors used them to treat infections a century ago, but antibiotics, patchy results and the Cold War pushed phage medicine aside in the West. As drug-resistant infections spread, with antibiotic resistance projected to contribute to more than eight million deaths a year by 2050, phages are back in focus. A big obstacle is that most of their genes have unknown functions, and most knowledge comes from a few well-studied phages. A new method pinpoints which genes a phage needs to function and can insert new genetic material into its genome within days. This could allow researchers to engineer phages that are better at attacking harmful bacteria.

so what

Phages can target one kind of bacteria and leave the others alone, and bacteria that dodge antibiotics may still fall to them. Making them easier to study and engineer is a step toward practical treatments.

fun fact

Phages look like tiny spacecraft, with geometric heads and spindly legs that they use to latch onto bacteria.

The Conversation

Illustrative photo · Kornienko MA, Malakhova MV, Bespiatykh DA, Manuvera VA, Sel…, CC BY 4.0, via Wikimedia Commons