science & techanalysisThe Conversation
PFAS leave fingerprints in your blood – researchers are figuring out how forever chemicals transform in your body to read these clues
PFAS, known as forever chemicals, are so persistent that they show up in human blood, breast milk and even penguins. They are used in nonstick cookware, food packaging, cosmetics and firefighting foam because their carbon-fluorine bonds resist breaking down. Once inside the body, some PFAS build up far more than others, so the chemical mix in blood differs from the mix someone was exposed to. PFOS in blood can reach 50 to 100 times the level in drinking water, because the body absorbs it faster than it excretes it. Many different PFAS also transform in the body into a few highly persistent compounds, such as PFOS, which makes the original source hard to trace.
Fluorinated carbon chains are extremely stable, so the molecules resist breakdown. PFAS that bind to proteins and fats accumulate in the body, while others are excreted. Metabolism can change many PFAS into a shared end product that retains the fluorinated backbone.
Scientists need to know these transformations to link exposure to its source, for example to firefighters who suspect their foams caused cancer. Without that link, regulations and personal choices are harder to base on evidence.
Persistent pollutants such as PCBs and DDT also accumulated in the bodies of animals and people over decades, and tracing their sources took many years of research.
Illustrative photo · Yanishevsky, CC BY-SA 4.0, via Wikimedia Commons
