historyOur World in Data1980s–1990s
Combination HIV drug therapy turned a death sentence into a manageable chronic illness
In the 1980s and 1990s HIV deaths rose rapidly, even though several effective antiretroviral drugs existed. The virus evolved to evade each drug on its own, so patients kept dying. The breakthrough was highly active antiretroviral therapy, which combines several drugs that attack the virus in different ways. Taking the drugs together made it much harder for the virus to adapt, and it kept levels suppressed in the body. Over time, treatment became widely available in many countries, changing HIV from a fatal diagnosis into a long-term condition for people who stay on treatment. Our World in Data tracks how deaths fell as access expanded.
Combination therapy is one of the most consequential medical advances of recent decades, saving millions of lives and making prevention of transmission possible through treatment. It also shows how combining imperfect tools can beat a pathogen that adapts to any single drug.
background
The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs as a strategy to control HIV infection. There are several classes of antiretroviral agents that act on different stages of the replication cycle of HIV. The use of multiple drugs that act on different viral targets is known as highly active antiretroviral therapy (HAART). HAART decreases the patient's total burden of HIV, maintains function of the immune system, and prevents opportunistic infections that often lead to death. HAART also prevents the transmission of HIV between serodiscordant same-sex and opposite-sex partners so long as the HIV-positive partner maintains an undetectable viral load.
From Wikipedia: Management of HIV/AIDS (CC BY-SA 4.0) ↗