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science & techNLM Circulating Now1953 · Cambridge, England

National DNA Day: Reflecting on Crick and Watson

the gist

On 25 April 1953, James Watson and Francis Crick published a one-page paper in the journal Nature proposing the double-helix structure of DNA. The twisted-ladder model had base pairs of adenine with thymine and cytosine with guanine on the inside of two sugar-phosphate backbones. The pairing immediately suggested how DNA could be copied, since each strand determines the other. Their work drew on Chargaff's base ratios, Rosalind Franklin and Maurice Wilkins's X-ray images, and Jerry Donohue's correction of the base chemistry. The model later explained how genes control protein synthesis and became the foundation of molecular biology and modern biotechnology.

so what

The double helix is the basis for genetic engineering, DNA fingerprinting and gene sequencing. Seeing how a one-page paper led to much of modern medicine and forensics makes the discovery easier to appreciate.

fun fact

Crick and Watson decided the order of their names in the Nature paper with a coin toss.

U.S. National Library of Medicine