historyWellcome Collection1847–1930s · Edinburgh, Scotland
Chloroform went from a party drug in Edinburgh to a staple of Victorian crime fiction
Scottish obstetrician James Simpson was searching for a better anaesthetic than ether in 1847, and his group tested chloroform at parties. Simpson then used it in childbirth within a week, and Queen Victoria's use of it in 1853 helped persuade mothers it was safe. During the US Civil War, surgeons used it widely on the wounded, especially for amputations. Its reputation as a knockout drug also made it a favourite device in novels, but in reality it could not silence someone in a few seconds, and it was later abandoned after accidental deaths.
Chloroform is a volatile liquid that evaporates into vapour which, inhaled, depresses the brain and produces unconsciousness. Dosing was hard to control, which led to overdoses and deaths, and it was gradually replaced by safer agents.
Chloroform shows how an anaesthetic's acceptance depended on celebrity endorsement and war. The gap between how it worked in fiction and in practice also reveals how crime stories shaped public fears.
Medical discoveries that were later exploited by crime fiction recur in history, and fiction often exaggerates the speed and reliability of such drugs, a pattern that continues in modern thrillers.
Queen Victoria used chloroform during the birth of her eighth child, Leopold, in 1853.
Wellcome Collection · CC BY 4.0
Illustrative photo · Danny S., CC BY-SA 3.0, via Wikimedia Commons
