AI helps Stanford scientists discover a “natural Ozempic” with a surprising advantage

from ScienceDaily

Stanford researchers have discovered an AI-identified natural molecule that dramatically suppresses appetite and promotes fat loss in animals, potentially offering an Ozempic-like weight-loss treatment without common digestive side effects or significant muscle loss. Called BRP, the molecule reduced food intake by up to 50% and targets a different brain pathway, raising hopes for a more precise obesity treatment if future human trials prove successful.

explained

Semaglutide is an anti-diabetic medication used for the treatment of type 2 diabetes, and an anti-obesity medication used for weight management. It can be administered by subcutaneous injection or taken orally. It is sold as a generic drug by several drug companies in the Indian and Canadian markets, and worldwide by its originator, Novo, under the brand names Ozempic and Rybelsus for diabetes; under the brand name Wegovy for weight management; and under the brand names Wegovy and Kayshild for the treatment of metabolic-associated steatohepatitis (nonalcoholic steatohepatitis) and liver cirrhosis. Wegovy is also used to reduce the risk of heart attacks.

Semaglutide is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain, and acts as a GLP-1 receptor agonist. The most common side effects include nausea, vomiting, diarrhea, abdominal pain, and constipation.

Semaglutide was approved for medical use in the United States in 2017, in Canada, the European Union and Japan in 2018, and in Australia in 2019. In 2024, it was the fourteenth most commonly prescribed medication in the United States, with more than 40 million prescriptions. It is on the World Health Organization's List of Essential Medicines.

From Wikipedia: Semaglutide (CC BY-SA 4.0) ↗

so what

If it holds up in people, it could offer a weight-loss option that avoids some of the drawbacks of current treatments. For now it is an early result in animals.

D. W. Griffith’s A Corner in Wheat (1909)

the gist

In 1909 D. W. Griffith made a 14-minute film about a speculator who corners the wheat market and doubles the price of bread. A farmer sows his field while a 'Wheat King' gambles in the Chicago wheat pit; bakers raise the loaf from five cents to ten and the poor line up for bread. Griffith cut back and forth between the farm, the feast and the breadline, a technique called parallel editing, so audiences saw both ends of the economy at once. The film drew on Frank Norris's stories and on a real scheme: months earlier Chicago financier James Patten had cornered wheat, sent bread prices up and made about $5 million, roughly $185 million today.

how it works

To corner a market, a trader buys up most of the available supply and the futures contracts that promise more. Anyone who has to deliver the commodity must then buy from the cornerer at whatever price is demanded. The trader profits until the stock is released or the scheme collapses.

so what

A century on, it still shows how markets can be rigged by someone who controls supply, and how the people at either end, farmers and eaters, pay for it. It also helped establish editing as a way to argue a point, not just tell a story.

the bigger pattern

Corners have recurred whenever supply could be locked up, from the Hunt brothers' attempt on silver in 1979 to 1980 to the 'Black Friday' gold panic of 1869. Many such schemes end by collapsing, and the response is often new rules on speculation.

fun fact

In the film the Wheat King dies by falling into a grain elevator and being buried in the wheat he hoarded, an ending borrowed from Norris's novel The Octopus.

Usman Khawaja refuses to answer Sandpapergate question about Pat Cummins | 7.30

from ABC News In-depth

One of the darkest days in Australia's sporting history has been dragged back into the spotlight.

A new autobiography by former Test cricketer Usman Khawaja has made explosive revelations about the Australian Test team's 2018 ball-tampering saga in South Africa.

7.30 host Sarah Ferguson speaks to Usman Khawaja.

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on YouTube: ABC News In-depth ↗