Why heart attacks can still happen even when bad cholesterol is low

from ScienceDaily

Even when bad cholesterol is brought down to healthy levels, some people remain at risk of heart attacks, and scientists may have discovered why. Researchers identified two types of fat-carrying particles that appear to promote inflammation and damage blood vessels through mechanisms beyond cholesterol buildup.

explained

A lipoprotein is a biochemical assembly whose primary function is to transport hydrophobic lipid (also known as fat) molecules in water, as in blood plasma or other extracellular fluids. They consist of a triglyceride and cholesterol center, surrounded by a phospholipid outer shell, with the hydrophilic portions oriented outward toward the surrounding water and lipophilic portions oriented inward toward the lipid center. A special kind of protein, called apolipoprotein, is embedded in the outer shell, both stabilising the complex and giving it a functional identity that determines its role.

Plasma lipoprotein particles are commonly divided into five main classes, based on size, lipid composition, and apolipoprotein content. They are, in increasing size order: HDL, LDL, IDL, VLDL and chylomicrons. Subgroups of these plasma particles are primary drivers or modulators of atherosclerosis.

Many enzymes, transporters, structural proteins, antigens, adhesins, and toxins are sometimes also classified as lipoproteins, since they are formed by lipids and proteins.

From Wikipedia: Lipoprotein (CC BY-SA 4.0) ↗ · text CC BY-SA 4.0

how it works

Blood vessels can be damaged when certain lipoprotein particles trigger inflammation in artery walls, which makes plaques grow and rupture. Lowering LDL cholesterol removes one trigger but leaves others untouched.

so what

It suggests that LDL alone is an incomplete risk measure. Future tests and drugs may target these particles and inflammation, not only cholesterol.

fun fact

Cholesterol is carried in the blood inside particles called lipoproteins because fat does not mix with water.

Indonesia's vice president Gibran Rakabuming Raka resigns over eligibility and credentials questions

the gist

Indonesian Vice President Gibran Rakabuming Raka handed his resignation to parliament after questions were raised about his eligibility for office and his academic credentials. Gibran is the son of former president Joko Widodo, and his resignation came as Widodo publicly backed the president, Prabowo Subianto. Gibran had been elected vice president in 2024 as Prabowo's running mate. His candidacy was made possible by a 2023 Constitutional Court ruling on the minimum age for candidates, which was itself controversial. Parliament will now consider the resignation.

so what

The vice presidency is the constitutional successor role to the presidency, so the vacancy matters for who would stand in if the president could not serve.

fun fact

Indonesia is the world's largest archipelagic state, with more than 17,000 islands.

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Data: GDELT Project

Illustrative photo · Jayakatwang, Public domain, via Wikimedia Commons

10:49

supplementary video · Epimetheus on YouTube ↗

world cultures & travelWikivoyageclassic9th–15th century · Siem Reap, Cambodia

Angkor was the largest pre-industrial city on Earth, covering about 3,000 square kilometres

the gist

Angkor, near Siem Reap in northern Cambodia, was the capital of the Khmer Empire, which ruled much of mainland Southeast Asia between roughly the 9th and 15th centuries. At its height the city spread across about 3,000 square kilometres, making it the largest pre-industrial city on Earth by area. Its growth depended on water: huge reservoirs called barays, along with canals and embankments, stored monsoon rain and carried it to rice fields. That system let farmers harvest more than once a year and fed a very large population through the dry season. The temple complex of Angkor Wat, built in the early 12th century, is the best-known monument and still stands at the heart of the park.

how it works

The Khmer kings built enormous rectangular reservoirs that caught monsoon rain during the wet season. Earthen dykes and canals moved that water into rice paddies, so farmers could grow crops across much of the year. The surplus food supported craftsmen, builders and the workforce that raised the temples.

so what

Angkor shows how a society without industrial machinery could build a city on a scale that rivals modern metropolises, using engineering and water management instead. Some historians link its decline to drought, flooding and shifts in its water systems, which makes it a long-running case study in how cities depend on managing water. The site is a UNESCO World Heritage Site and one of the most important archaeological landscapes in Southeast Asia.

fun fact

The outline of Angkor Wat appears on the national flag of Cambodia.