Genes help decide how your body handles medicine, for instance how fast the liver breaks a drug down and how long it lingers in the blood. Analysing whole genomes and health records of nearly 100,000 people in the US All of Us programme, researchers examined 16 well-established drug-response genes. Every participant carried at least one relevant variant, and about 99.5% had one for which the FDA or medical guidelines recommend a different drug or dose for certain medications. Around 24% had already taken a drug affected by a variant they carry, including stomach-acid drugs like omeprazole and cholesterol-lowering statins. The team also found 17,704 previously unreported variants in these genes.

Israeli reports also say the cabinet directed the military to prepare for a possible new attack on Iran.

Angkor, near Siem Reap in northern Cambodia, was the capital of the Khmer Empire, which ruled much of mainland Southeast Asia between roughly the 9th and 15th centuries. At its height the city spread across about 3,000 square kilometres, making it the largest pre-industrial city on Earth by area. Its growth depended on water: huge reservoirs called barays, along with canals and embankments, stored monsoon rain and carried it to rice fields. That system let farmers harvest more than once a year and fed a very large population through the dry season. The temple complex of Angkor Wat, built in the early 12th century, is the best-known monument and still stands at the heart of the park.