Pfizer was testing a heart drug when it stumbled on what would become Viagra

historyWikipedia1989

Pfizer was testing a heart drug when it stumbled on what would become Viagra

the gist

In 1989, the pharmaceutical company Pfizer was searching for a treatment for high blood pressure and angina. Its experimental compound, sildenafil citrate, produced an unexpected side effect: it increased blood flow to certain areas of the body. Pfizer saw a new market in that effect and gave the drug a name that evoked vitality and Niagara, Viagra. The drug was later approved in 1998 for erectile dysfunction, and it became one of the best-known medicines ever sold. The episode is a classic case of serendipity, where a failed research goal turned into a blockbuster product.

so what

Viagra shows how a side effect observed in a trial can redirect an entire drug programme. It also shows how a marketing name can shape how the public understands a medicine. Sildenafil's history is a useful example of how discovery in pharmaceuticals often depends on noticing the unexpected.

fun fact

Sildenafil was later developed into a separate treatment for pulmonary arterial hypertension, a serious lung condition, sold under the name Revatio.

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background

Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. It is unclear if it is effective for treating sexual dysfunction in females. It can be taken orally (swallowed by mouth), intravenously (injection into a vein), or through the sublingual route (dissolved under the tongue). Onset when taken orally is typically within twenty minutes and lasts for about two hours.

Common side effects include headaches, heartburn, and flushed skin. Caution is advised in those with cardiovascular disease. Rare but serious side effects include vision problems, hearing loss, and prolonged erection (priapism) that can lead to damage to the penis. Sildenafil should not be taken by people on nitric oxide donors such as nitroglycerin, as this may result in a serious drop in blood pressure.

From Wikipedia: Sildenafil (CC BY-SA 4.0) ↗ · text CC BY-SA 4.0

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source: Wikipedia ↗

politics

Trump and Netanyahu reportedly clash over whether to resume military action against Iran

the gist

Israeli reports also say the cabinet directed the military to prepare for a possible new attack on Iran.

so what

The United States and Israel have been closely aligned on Iran's nuclear programme and regional threats, so open disagreement between their leaders over military strategy is unusual and closely watched. Whether to resume strikes is a decision with consequences for shipping, oil markets and the wider Middle East.

fun fact

Benjamin Netanyahu has served as Prime Minister of Israel for more years in total than any other person.

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Data: GDELT Project

Illustrative photo · Israel Belkind and Fanny Abramovitch (original) “The Provis…, Public domain, via Wikimedia Commons

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supplementary video · Epimetheus on YouTube ↗

world cultures & travelWikivoyageclassic9th–15th century · Siem Reap, Cambodia

Angkor was the largest pre-industrial city on Earth, covering about 3,000 square kilometres

the gist

Angkor, near Siem Reap in northern Cambodia, was the capital of the Khmer Empire, which ruled much of mainland Southeast Asia between roughly the 9th and 15th centuries. At its height the city spread across about 3,000 square kilometres, making it the largest pre-industrial city on Earth by area. Its growth depended on water: huge reservoirs called barays, along with canals and embankments, stored monsoon rain and carried it to rice fields. That system let farmers harvest more than once a year and fed a very large population through the dry season. The temple complex of Angkor Wat, built in the early 12th century, is the best-known monument and still stands at the heart of the park.

how it works

The Khmer kings built enormous rectangular reservoirs that caught monsoon rain during the wet season. Earthen dykes and canals moved that water into rice paddies, so farmers could grow crops across much of the year. The surplus food supported craftsmen, builders and the workforce that raised the temples.

so what

Angkor shows how a society without industrial machinery could build a city on a scale that rivals modern metropolises, using engineering and water management instead. Some historians link its decline to drought, flooding and shifts in its water systems, which makes it a long-running case study in how cities depend on managing water. The site is a UNESCO World Heritage Site and one of the most important archaeological landscapes in Southeast Asia.

fun fact

The outline of Angkor Wat appears on the national flag of Cambodia.